AMINO ACIDS

Amino Acids LC-MS/MS Analysis Kit

In recent years metabolomics has facilitated gaining insight into discovering the potential disease diagnostic markers and observing fluctuations of certain metabolite levels in body fluids. Disease-related metabolites can be uncovered by following progress of the new methodologies which enable to identify a broad range of diagnostic biomarker candidates including amino acids. Owing to the vital roles of amino acids in metabolic regulations (protein synthesis, neurotransmission, hormone secretion, and immunity), they have become significant targets while taking snapshot of metabolic status. Therefore, elucidation of the circulating amino acids profile alterations by utilizing robust analysis method could shed light on not only in metabolic diseases but also in certain disorders such as autism, prostate cancer, Huntington’s disease, Parkinson’s disease, Alzheimer’s disease, obesity, type 2 diabetes, liver cirrhosis, major depressive disorder, and cardiovascular disease.

  • Highlights

    Quantitative analysis of underivatized 43 amino acids in 7.5 min. In need of determining allo-Isoleucine for MSUD, extra injection takes 11.0 min. (Leucine/Isoleucine/allo-Isoleucine).

    One sample preparation for all amino acids-one vial for both abovementioned methods.

    Just a few pipetting steps for the sample preparation; for plasma/serum-protein crash and shoot for urine-dilute and shoot.

    Clinically important amino acids safeguarded by its own internal standard.

    Consuming small volume of patient’s sample.

    Long life span of HPLC column-up to 10000 injections.
  • Parameters

    Alanine, Arginine, Aspartic acid, Asparagine, 2-Aminobutyric acid, Argininosuccinic acid, Anserine, 2-Aminoadipic acid, 3-Aminoisobutyric acid, β-Alanine, Ethanolamine, Phenylalanine, ortho-Phosphoserine, ortho-Phosphorylethanolamine, γ-Aminobutyric acid, Glutamic acid, Glycine, Glutamine, trans-4-Hydroxyproline, Homocitrulline, Homocystine, Histidine, 5-Hydroxylysine, Isoleucine, Carnosine, Lysine, Leucine, Allo-Isoleucine, Methionine, 3-Methylhistidine, 1- Methylhistidine, Norvaline, Ornithine, Proline, Cystine, Cystathionine, Sarcosine, Citrulline, Serine, Taurine, Tryptophan, Tyrosine, Threonine and Valine.
  • Matrix

    Serum/Plasma, Urine

Sample Preparation

Plasma/Serum

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Sample Preparation

Urine

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