Serotonin in Plasma

Serotonin LC-MS/MS Kit

Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter synthesized from the amino acid tryptophan. Most of total body serotonin is found in the gastrointestinal (GI) tract, where it modulates the functions of the bowel by controlling smooth muscle contraction. It also acts as a cardiovascular vasoconstriction mediator and in the brain as a neurotransmitter.Neuroendocrine neoplasms (NENs), which originate from GI tract enterochromaffin cells, may produce large amounts of serotonin.

Jasem kit allows quantification of serotonin in plasma without using SPE throughout 5 minutes. 

  • Features

    • Analysis of serotonin without derivatization 

    • No need of SPE! Rapid and easy sample preparation-just protein precipitation! 

    • 5 minutes analysis time from injection to injection

  • Matrix

    • Plasma
  • Extracted ion chromatogram of serotonin

  • Retention times of serotonin

                   Analyte

    Retention Times(min)

            Serotonin

                 3.57

  • Linearity & Limit of Quantitation

          

     

    PLASMA

    Analyte

    R2

    LOQ

    (µg/L)

    Serotonin

    0.998

    3.98

  • Recovery

    Analyte

    Concentration µg/L (plasma)

    Recovery %

    Serotonin

    225.0

    94.4

  • Repeatability

    Analyte

    Concentration µg/L (plasma)

    CV %

    Serotonin

    100.0

    0.39

ADAPTING DIAGNOSTICS IN CHROMATOGRAPHY COUPLED MASS SPECTROMETRY..

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