IMMUNOSUPPRESIVE DRUGS

Immunosuppressive Drugs in Whole Blood LC-MS/MS Analysis Kit

Tacrolimus, sirolimus, everolimus and Cyclosporine A are immunosuppressive drugs used in organ transplantation in order to prevent the rejection of transplanted organs and tissues. In addition, they are used in the therapy of autoimmune diseases. Due to high pharmacokinetic variability, narrow therapeutic indexes and many potential drug-drug interactions, close monitoring of blood concentrations is required to prevent rejection and minimize toxicity. The quantitative determination of these immunosuppressants should be performed only with LC-MS/MS, because the immunological tests vary considerably in terms of selectivity and specificity, and sometimes also detect inactive metabolites.

  • Highlights

    Simultaneous measurement the concentrations of 4 immunosuppressive drugs.

    Total run time is 7.5 min.

    Simple sample preparation-protein precipitate and shoot approach, no need for online sample preparation using the trap column technique.

    Whole blood based multi-level calibrator and control.

    Long life span of HPLC column.
  • Parameters

    Tacrolimus, Everolimus, Sirolimus and Cyclosporine A.
  • Matrix

    Whole blood

Sample Preparation


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