Multi-Mycotoxins in Baby Food
Mycotoxins are secondary metabolites produced by molds, without biochemical significance in fungal growth and development. Although they have existed since ancient times, the term mycotoxins appeared in 1960 when 100 000 turkey poults died due to the ingestion of peanut contaminated with secondary metabolites from Aspergillus flavus.
Mycotoxins are compounds with various chemical structures and, therefore, various biological effects in animals and humans such as toxic, carcinogenic, estrogenic, mutagenic, teratogenic, and immunotoxic effects.
In Europe, Commission Regulation (EC) No 1881/2006 and its amendments set maximum residue levels (MRLs) for 13 mycotoxins.
Jasem multi-mycotoxin method analyzes 10 mycotoxins in one injection and HT-2 and DON are analyzed in second injection with same sample, same column and same instrument parameters except HPLC program.
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Chromatogram
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METHOD PERFORMANCE
LOQ
AFB1
AFB2
AFG1
AFG2
DON
FB1
FB2
HT2
OTA
STE
T2
ZON
Conc. (µg/kg)
0,05
0,20
0,27
0,28
21,93
5,46
5,50
4,74
0,10
0,13
1,09
1,10
R2
0,998
0,997
0,997
0,998
0,997
0,998
0,998
0,997
0,997
0,999
0,998
0,997
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Repeatability
Level 1
AFB1
AFB2
AFG1
AFG2
DON
FB1
FB2
HT2
OTA
STE
T2
ZON
Conc. (µg/kg)
0,3125
0,3125
0,3125
0,3125
31,25
31,25
9,375
31,25
0,3125
0,3125
3,125
3,125
RSD (%)
4,61
4,06
4,84
7,60
2,06
5,00
2,94
8,69
9,84
5,94
10,03
5,41
Level 2
FB1
FB2
HT2
OTA
STE
T2
ZON
Conc. (µg/kg)
0,625
0,625
0,625
0,625
62,5
62,5
18,75
62,5
0,625
0,625
6,25
6,25
RSD (%)
7,27
4,9
3,41
6,71
5,52
3,27
2,96
8,00
3,65
3,53
4,78
3,93
Level 3
FB1
FB2
HT2
OTA
STE
T2
ZON
Conc. (µg/kg)
1,25
1,25
1,25
1,25
125
125
37,5
125
1,25
1,25
12,5
12,5
RSD (%)
1,17
2,05
3,33
3,35
4,09
3,3
2,38
2,53
3,9
2,56
4,85
1,37
Level 4
FB1
FB2
HT2
OTA
STE
T2
ZON
Conc. (µg/kg)
1,875
1,875
1,875
1,875
187,5
187,5
56,25
187,5
1,875
1,875
18,75
18,75
RSD (%)
2,32
2,86
2,17
5,54
2,00
3,8
2,17
2,07
3,11
1,83
5,51
4,83
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reproducibility
Level 1
AFB1
AFB2
AFG1
AFG2
DON
FB1
FB2
HT2
OTA
STE
T2
ZON
Conc. (µg/kg)
0,3125
0,3125
0,3125
0,3125
31,25
31,25
9,375
31,25
0,3125
0,3125
3,125
3,125
RSD (%)
4,87
6,98
4,59
5,23
3,49
5,08
3,21
3,12
10,54
7,09
5,83
7,48
Level 2
FB1
FB2
HT2
OTA
STE
T2
ZON
Conc. (µg/kg)
0,625
0,625
0,625
0,625
62,5
62,5
18,75
62,5
0,625
0,625
6,25
6,25
RSD (%)
7,97
4,61
6,75
14,61
4,43
5,53
2,81
8,23
10,06
10,1
9,48
6,75
Level 3
FB1
FB2
HT2
OTA
STE
T2
ZON
Conc. (µg/kg)
1,25
1,25
1,25
1,25
125
125
37,5
125
1,25
1,25
12,5
12,5
RSD (%)
6,55
4,81
5,44
12,72
5,80
6,50
4,53
4,93
7,13
5,40
5,68
3,96
Level 4
FB1
FB2
HT2
OTA
STE
T2
ZON
Conc. (µg/kg)
1,875
1,875
1,875
1,875
187,5
187,5
56,25
187,5
1,875
1,875
18,75
18,75
RSD (%)
5,28
4,14
4,40
11,54
3,21
5,66
4,99
4,34
7,02
9,40
6,73
4,20
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recovery
Level 1
AFB1
AFB2
AFG1
AFG2
DON
FB1
FB2
HT2
OTA
STE
T2
ZON
Conc. (µg/kg)
0,3125
0,3125
0,3125
0,3125
31,25
31,25
9,375
31,25
0,3125
0,3125
3,125
3,125
Recovery (%)
105,73
110,35
110,80
111,46
115,43
82,55
94,20
105,81
107,46
102,77
106,10
105,95
Level 2
FB1
FB2
HT2
OTA
STE
T2
ZON
Conc. (µg/kg)
0,625
0,625
0,625
0,625
62,5
62,5
18,75
62,5
0,625
0,625
6,25
6,25
Recovey (%)
98,11
102,00
102,34
96,30
108,67
82,53
92,97
97,94
91,17
100,27
96,47
107,61
Level 3
FB1
FB2
HT2
OTA
STE
T2
ZON
Conc. (µg/kg)
1,25
1,25
1,25
1,25
125
125
37,5
125
1,25
1,25
12,5
12,5
Recovery (%)
101,24
101,47
95,55
92,43
101,87
89,90
94,60
98,94
94,52
96,04
96,05
110,65
Level 4
FB1
FB2
HT2
OTA
STE
T2
ZON
Conc. (µg/kg)
1,875
1,875
1,875
1,875
187,5
187,5
56,25
187,5
1,875
1,875
18,75
18,75
Recovery (%)
103,10
105,32
101,24
99,08
99,20
93,70
100,27
108,37
98,12
99,08
99,62
112,60
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