Catecholamines, Free Metanephrines and Serotonin in Urine LC-MS/MS Analysis Kit
The major metabolites of catecholamines secreted by the adrenal glands in case of stress are metanephrine, epinephrine, normetanephrine and norepinephrine. These biomarkers are evaluated to determine urinary concentration of them in people with suspected pheochromocytoma. This disease is a very rare tumour and causes hypertension in non-followed cases. It is very important to accurately diagnose before surgical intervention and by looking at the catecholamine derivatives, it is possible to diagnose pheochromocytoma.
Jasem presents this analysis reliably on LC-MS/MS with free metanephrine, catecholamine and serotonin kit in urine.
Chromatogram
METHOD PERFORMANCE
| Analytes | LOQ Agilent 6460 (µg/L) | LOQ Agilent 6470 (µg/L) | Accuracy Agilent 6470 (%) | Repeatability Agilent 6470 (%RSD) | Linearity Agilent 6470 (R2) |
| Epinephrine | 11.04 | 0.5 | 106 | 5,6 | 0,996 |
| Norepinephrine | 20.96 | 1.0 | 96 | 3,6 | 0,997 |
| Dopamine | 36.68 | 5.0 | 104 | 4,2 | 0,994 |
| Metanephrine | 11.9 | 1.6 | 102 | 5,6 | 0,995 |
| Normetanephrine | 12.15 | 1.8 | 105 | 6,4 | 0,992 |
| 3-Methoxytyramine | 43.38 | 15.0 | 107 | 4,6 | 0,996 |
| Serotonin | 29.21 | 12.0 | 96 | 2,5 | 0,998 |